Tadasoft 20 mg should not be taken by individuals who are allergic to Tadalafil or any other ingredients in the medication, as well as those taking medications containing nitrates (such as nitroglycerin) for chest pain or heart problems, as this combination can cause a dangerous drop in blood pressure. Additionally, it's essential to discuss your medical history and any current medications with your healthcare provider before starting Tadasoft 20 mg to ensure it is safe for you to use.