After completing antibiotic treatment, about 10% of Lyme disease patients still have physical discomfort and cognitive difficulties. Post-Lyme disease syndrome, also known as post-treatment Lyme disease syndrome, can develop in people who have had Lyme disease. Both of these terms are interchangeable. The pathophysiology of PTLDS has sparked debate. It's difficult to imagine persons with PTLDS harbouring secret Borrelia burgdorferi reservoirs after antibiotic treatment.