Tadarise 60 mg works by inhibiting the enzyme PDE5. This enzyme typically breaks down cyclic guanosine monophosphate (cGMP), which is responsible for relaxing the smooth muscles in the blood vessels of the penis. By inhibiting PDE5, Tadalafil helps to increase the levels of cGMP, leading to smooth muscle relaxation and increased blood flow to the penis, thereby enabling an erection in response to sexual stimulation.