Combining ED medications is not typically recommended without medical supervision. Mixing PDE5 inhibitors like Tadarise 40 with Viagra, Levitra, or Cialis can lead to severe side effects, including dangerously low blood pressure, dizziness, and fainting. However, there may be scenarios where a healthcare provider might suggest combining treatments with different mechanisms, such as a PDE5 inhibitor and a penile injection, but this must be carefully monitored.